Search results for "inulin copolymer"

showing 2 items of 2 documents

Folate targeted coated SPIONs as efficient tool for MRI

2017

The development of more sensitive diagnostic tools allowing an early-stage and highly efficient medical imaging of tumors remains a challenge. Magnetic nanoparticles seem to be the contrast agents with the highest potential, if properly constructed. Therefore, in this study, hybrid magnetic nanoarchitectures were developed using a new amphiphilic inulin-based graft copolymer (INU-LAPEG-FA) as coating material for 10-nm spinel iron oxide (magnetite, Fe3O4) superparamagnetic nanoparticles (SPION). Folic acid (FA) covalently linked to the coating copolymer in order to be exposed onto the nanoparticle surface was chosen as the targeting agent because folate receptors are upregulated in many can…

magnetic resonance imaging (MRI)Materials sciencecancer targetingfolic acid (FA)NanoparticleNanotechnology02 engineering and technologyengineering.material010402 general chemistryDiagnostic tools01 natural sciencesCoatingsuperparamagnetic spinel iron oxide nanoparticles (SPIONs)AmphiphilemedicineGeneral Materials ScienceElectrical and Electronic Engineeringinulin copolymermedicine.diagnostic_testMagnetic resonance imaging021001 nanoscience & nanotechnologyCondensed Matter PhysicsAtomic and Molecular Physics and Optics0104 chemical sciencesMagnetic hyperthermiaFolic acidengineeringMagnetic nanoparticlesMaterials Science (all)0210 nano-technologyhuman activities
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Inulin-based polymer coated SPIONs as potential drug delivery systems for targeted cancer therapy

2014

This paper deal with the synthesis and characterization of PEGylated squalene-grafted-inulin amphiphile capable of self-assembling and self-organizing into nanocarriers once placed in aqueous media. It was exploited as coating agent for obtaining doxorubicin loaded superparamagnetic iron oxide nanoparticles (SPIONs) endowed with stealth like behavior and excellent physicochemical stability. Inulin was firstly modified in the side chain with primary amine groups, followed in turn by conjugation with squalenoyl derivatives through common amidic coupling agents and PEGylation by imine linkage. Polymer coated SPIONs were so obtained by spontaneous self-assembling of inulin copolymer onto magnet…

Hydrodynamic radiusCell SurvivalPolymersSurface PropertiesPharmaceutical ScienceTherapeutic indexSpectroscopy Fourier Transform InfraredAmphiphileZeta potentialmedicineSPIONs Inulin copolymer Doxorubicin Magnetic targeting Squalene PegylatedHumansOrganic chemistryDoxorubicinParticle SizeMagnetite NanoparticlesDrug CarriersAntibiotics AntineoplasticMolecular StructureChemistryInulinGeneral MedicineHCT116 CellsCombinatorial chemistryDrug LiberationDoxorubicinDrug deliveryMicroscopy Electron ScanningPEGylationNanocarriersBiotechnologymedicine.drugEuropean Journal of Pharmaceutics and Biopharmaceutics
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